Phosphatidylinositol 3-Kinase

Involvement of Phosphatidylinositol 3-Kinase

Calmodulin activates phosphatidylinositol 3-kinase.

Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector protein, regulates multiple processes in eukaryotic cells, including cytoskeletal organization, vesicular trafficking, and mitogenesis. Phosphatidylinositol 3-kinase participates in events downstream of the receptors for insulin and other...

Thymic Exit Phosphatidylinositol 3-Kinase Regulates

Phosphatidylinositol 3-kinase: a novel effector.

A number of years ago, when the raison d’#{234}tre for tyrosine kinase activity was completely unclear, one of the tantalizing leads was the apparent coincidence of inositol lipid kinase activity with certain tyrosine kinases (see, for example Refs. 1 and 2); the exciting prospect implied was a link to a well defined signal transduction pathway (for a review of inositol lipid kinases, see Ref. ...

Phosphatidylinositol 3-kinase signaling determines kidney size.

Kidney size adaptively increases as mammals grow and in response to the loss of 1 kidney. It is not clear how kidneys size themselves or if the processes that adapt kidney mass to lean body mass also mediate renal hypertrophy following unilateral nephrectomy (UNX). Here, we demonstrated that mice harboring a proximal tubule-specific deletion of Pten (Pten(ptKO)) have greatly enlarged kidneys as...